Myostatin Inhibitors – The Future of Bodybuilding?
Everyone knows that guy growing up that just had “it”. He didn’t go to the gym as much as you did but when he did he got bigger and stronger then you at a pace that seemed like a sprint. No matter what you did, you and all your lifting buddies could never look or lift anywhere near what this guy did. So is he a genetic freak? Well he most likely is a freak by some standards, now the question is how, and why?
There is a very good chance he and many others like this are Myostatin deficient. So what is Myostatin and what is its correlation to an increase in muscle mass?
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a protein that in humans, is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family that inhibits muscle differentiation and growth in the process known as myogenesis. Myostatin is produced primarily in skeletal muscle cells, circulates in the blood and acts on muscle tissue, by binding a cell-bound receptor called the activin type II receptor.
For the last 60 years since the former DDR(East Germany)introduced turinabol into their Olympic program to dominate the world in that year’s Olympics, athletes across the globe have searched, tried and experimented with many different prescription and experimental drugs to enhance their performance in the sport they competed in. The use of Myostatin inhibitors is just the next BIG step in that direction.
Several large Pharm companies in the last few years have put together in depth testing/trial programs to attempt to develop a safe Myostatin inhibitor or Myostatin receptor inhibitor, to be used by people with muscular dystrophy, AIDS, and any muscle wasting disease to help them reverse the effects of there diseases’. This was the initial purpose after Dr Se-Jin Lee at John’s Hopkins discovered Myostatin in 1992. Dr. Lee was able to inhibit Myostatin in mice, which resulted in their overall muscle mass to double in a short period of time.
So why would anyone want to block or inhibit Myostatin other than folks who may be suffering from one of the fatal diseases mentioned? Well just like EPO, HGH and many other effective FDA approved drugs, people want Myostatin inhibition so they can out size, and outperform their competitors.
In a sport like competitive bodybuilding PED (performance enhancing drug) use is common place. Many of the competitors or even followers of bodybuilding will go to great lengths to be on top of the hill. Research companies have already put out a various line of so called Myostatin inhibitors over the last few years. Actually not even a year after big Pharm Company Acceleron released studies on ACE-031 it began to show up in the online selections of Chemical Research Companies on various internet sites for anyone to buy for there “research”.
Around the same time came Follistatin, or “Folli” as it was called. This compound had some success as it first appeared on the scene, but quickly fell out of favor due to several bad batches that appeared for “research”. For several different assumed reasons it was very difficult for the research companies to acquire, and distribute a sound peptide of this nature. So we began to see a mild decline in the interest of Myostatin inhibitors in general, as online seller’s targeted new horizons with products that had some better consistency.
Bounce forward a few years to the present. It is of my opinion that pharmaceutical grade Myostatin inhibitors are now, and have been for the past few years available on the black market or some type of underground network. With companies like Wyeth, and Amgen seeing outstanding results from human trials on MYO-029 and more recently AMG-745.
It’s my belief they are in the hands of athletes looking for the latest performance enhancement. Myself like many of you have been around bodybuilding for many years. We all know what SEO, and various site oils look like. We have all seen guys on large HGH doses, and 3-4+g a week AAS cycles, with fast and slow acting insulin, and every GHRP and GHRH peptide thrown in with it. In recent years though, what has increasingly become more prevalent, is the bodybuilders going beyond a gram of Tren and 20ius of GH. There are some real “freaks” coming into the game as of late.
My opinion is still all speculation and has no solid evidence to stand on, but I think I’m right. The era of Myostatin inhibitors is upon us in bodybuilding. The “freak’ factor is about to go to another level!!
– S2H
Everyone knows that guy growing up that just had “it”. He didn’t go to the gym as much as you did but when he did he got bigger and stronger then you at a pace that seemed like a sprint. No matter what you did, you and all your lifting buddies could never look or lift anywhere near what this guy did. So is he a genetic freak? Well he most likely is a freak by some standards, now the question is how, and why?
There is a very good chance he and many others like this are Myostatin deficient. So what is Myostatin and what is its correlation to an increase in muscle mass?
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a protein that in humans, is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family that inhibits muscle differentiation and growth in the process known as myogenesis. Myostatin is produced primarily in skeletal muscle cells, circulates in the blood and acts on muscle tissue, by binding a cell-bound receptor called the activin type II receptor.
For the last 60 years since the former DDR(East Germany)introduced turinabol into their Olympic program to dominate the world in that year’s Olympics, athletes across the globe have searched, tried and experimented with many different prescription and experimental drugs to enhance their performance in the sport they competed in. The use of Myostatin inhibitors is just the next BIG step in that direction.
Several large Pharm companies in the last few years have put together in depth testing/trial programs to attempt to develop a safe Myostatin inhibitor or Myostatin receptor inhibitor, to be used by people with muscular dystrophy, AIDS, and any muscle wasting disease to help them reverse the effects of there diseases’. This was the initial purpose after Dr Se-Jin Lee at John’s Hopkins discovered Myostatin in 1992. Dr. Lee was able to inhibit Myostatin in mice, which resulted in their overall muscle mass to double in a short period of time.
So why would anyone want to block or inhibit Myostatin other than folks who may be suffering from one of the fatal diseases mentioned? Well just like EPO, HGH and many other effective FDA approved drugs, people want Myostatin inhibition so they can out size, and outperform their competitors.
In a sport like competitive bodybuilding PED (performance enhancing drug) use is common place. Many of the competitors or even followers of bodybuilding will go to great lengths to be on top of the hill. Research companies have already put out a various line of so called Myostatin inhibitors over the last few years. Actually not even a year after big Pharm Company Acceleron released studies on ACE-031 it began to show up in the online selections of Chemical Research Companies on various internet sites for anyone to buy for there “research”.
Around the same time came Follistatin, or “Folli” as it was called. This compound had some success as it first appeared on the scene, but quickly fell out of favor due to several bad batches that appeared for “research”. For several different assumed reasons it was very difficult for the research companies to acquire, and distribute a sound peptide of this nature. So we began to see a mild decline in the interest of Myostatin inhibitors in general, as online seller’s targeted new horizons with products that had some better consistency.
Bounce forward a few years to the present. It is of my opinion that pharmaceutical grade Myostatin inhibitors are now, and have been for the past few years available on the black market or some type of underground network. With companies like Wyeth, and Amgen seeing outstanding results from human trials on MYO-029 and more recently AMG-745.
It’s my belief they are in the hands of athletes looking for the latest performance enhancement. Myself like many of you have been around bodybuilding for many years. We all know what SEO, and various site oils look like. We have all seen guys on large HGH doses, and 3-4+g a week AAS cycles, with fast and slow acting insulin, and every GHRP and GHRH peptide thrown in with it. In recent years though, what has increasingly become more prevalent, is the bodybuilders going beyond a gram of Tren and 20ius of GH. There are some real “freaks” coming into the game as of late.
My opinion is still all speculation and has no solid evidence to stand on, but I think I’m right. The era of Myostatin inhibitors is upon us in bodybuilding. The “freak’ factor is about to go to another level!!
– S2H
via World Class Bodybuilding Forum http://www.worldclassbodybuilding.com/forums/f485/myostatin-inhibitors-the-future-of-bodybuilding-138117/
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