The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling.
Am J Physiol Endocrinol Metab. 2014 Jan 22;
Authors: Long YC, Tan TM, Inoue T, Tang BL
Abstract
Cellular and organ metabolism affects organismal lifespan. Aging is characterized by increased risks for metabolic disorders, with age-associated degenerative diseases exhibiting varying degrees of mitochondrial dysfunction. The traditional view of the role of mitochondria generated reactive oxygen species (ROS) in cellular aging, assumed to be causative and simply detrimental for a long time now, is in need of reassessment. While there is little doubt that high levels of ROS are detrimental, mounting evidence points towards a lifespan extension effect exerted by mild to moderate ROS elevation. Dietary caloric restriction (CR), inhibition of insulin-like growth factor (IGF)-1 signaling, and inhibition of the nutrient-sensing mechanistic target of rapamycin (mTOR) are robust longevity promoting interventions. All of these appear to elicit mitochondrial retrograde signaling processes (defined as signaling from the mitochondria to the rest of the cell, for example, the mitochondrial unfolded protein response, or UPR(mt)). The effects of mitochondrial retrograde signaling may even spread to other cells/tissues in a non-cell autonomous manner by yet unidentified signaling mediators. Multiple recent publications support the notion that an evolutionarily conserved, mitochondria-initiated signaling is central to the genetic and epigenetic regulation of cellular aging and organismal lifespan.
PMID: 24452454 [PubMed - as supplied by publisher]
More...
Insulin like growth factors
IGF-1
Igf-1r3
This has been a World Class Bodybuilding automated thread
Am J Physiol Endocrinol Metab. 2014 Jan 22;
Authors: Long YC, Tan TM, Inoue T, Tang BL
Abstract
Cellular and organ metabolism affects organismal lifespan. Aging is characterized by increased risks for metabolic disorders, with age-associated degenerative diseases exhibiting varying degrees of mitochondrial dysfunction. The traditional view of the role of mitochondria generated reactive oxygen species (ROS) in cellular aging, assumed to be causative and simply detrimental for a long time now, is in need of reassessment. While there is little doubt that high levels of ROS are detrimental, mounting evidence points towards a lifespan extension effect exerted by mild to moderate ROS elevation. Dietary caloric restriction (CR), inhibition of insulin-like growth factor (IGF)-1 signaling, and inhibition of the nutrient-sensing mechanistic target of rapamycin (mTOR) are robust longevity promoting interventions. All of these appear to elicit mitochondrial retrograde signaling processes (defined as signaling from the mitochondria to the rest of the cell, for example, the mitochondrial unfolded protein response, or UPR(mt)). The effects of mitochondrial retrograde signaling may even spread to other cells/tissues in a non-cell autonomous manner by yet unidentified signaling mediators. Multiple recent publications support the notion that an evolutionarily conserved, mitochondria-initiated signaling is central to the genetic and epigenetic regulation of cellular aging and organismal lifespan.
PMID: 24452454 [PubMed - as supplied by publisher]
More...
Insulin like growth factors
IGF-1
Igf-1r3
This has been a World Class Bodybuilding automated thread
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