When I had my most recent Blood work done I found out that I have the worst genotype possible for Apolipoprotein E.
ApoE is polymorphic with three major isoforms: ApoE2, ApoE3, and ApoE4. Although these allelic forms differ from each other by only one or two amino acids at positions 112 and 158 these differences alter apoE structure and function. These have physiological consequences:
E2 is found in approximately 7 percent of the population. This variant of the apoprotein binds poorly to cell surface receptors while E3 and E4 bind well. E2 is associated with both increased and decreased risk for atherosclerosis. Individuals with an E2/E2 combination may clear dietary fat slowly and be at greater risk for early vascular disease and the genetic disorder type III hyperlipoproteinemia—94.4% of such patients are E2/E2, while only ∼2% of E2/E2 develop the disease, so other environmental and genetic factors are likely to be involved (such as cholesterol in the diet and age). E2 has also been implicated in Parkinson's disease.
E3 is found in approximately 79 percent of the population. It is considered the "neutral" Apo E genotype.
E4 is found in approximately 14 percent of the population. E4 has been implicated in atherosclerosis, Alzheimer's disease, impaired cognitive function, reduced hippocampal volume, HIV, faster disease progression in multiple sclerosis, unfavorable outcome after traumatic brain injury, ischemic cerebrovascular disease, sleep apnea, and reduced neurite outgrowth.
The E4 variant is the largest known genetic risk factor for late-onset sporadic Alzheimer disease (AD) in a variety of ethnic groups. Caucasian and Japanese carriers of 2 E4 alleles have between 10 and 30 times the risk of developing AD by 75 years of age, as compared to those not carrying any E4 alleles.
Through blood work I've found out that I carry two E4 alleles
Am I pretty much screwed, how much will eating a healthy diet and training do to decrease my chances of all the horrible illness associate with people who only carry one E4 allele.
ApoE is polymorphic with three major isoforms: ApoE2, ApoE3, and ApoE4. Although these allelic forms differ from each other by only one or two amino acids at positions 112 and 158 these differences alter apoE structure and function. These have physiological consequences:
E2 is found in approximately 7 percent of the population. This variant of the apoprotein binds poorly to cell surface receptors while E3 and E4 bind well. E2 is associated with both increased and decreased risk for atherosclerosis. Individuals with an E2/E2 combination may clear dietary fat slowly and be at greater risk for early vascular disease and the genetic disorder type III hyperlipoproteinemia—94.4% of such patients are E2/E2, while only ∼2% of E2/E2 develop the disease, so other environmental and genetic factors are likely to be involved (such as cholesterol in the diet and age). E2 has also been implicated in Parkinson's disease.
E3 is found in approximately 79 percent of the population. It is considered the "neutral" Apo E genotype.
E4 is found in approximately 14 percent of the population. E4 has been implicated in atherosclerosis, Alzheimer's disease, impaired cognitive function, reduced hippocampal volume, HIV, faster disease progression in multiple sclerosis, unfavorable outcome after traumatic brain injury, ischemic cerebrovascular disease, sleep apnea, and reduced neurite outgrowth.
The E4 variant is the largest known genetic risk factor for late-onset sporadic Alzheimer disease (AD) in a variety of ethnic groups. Caucasian and Japanese carriers of 2 E4 alleles have between 10 and 30 times the risk of developing AD by 75 years of age, as compared to those not carrying any E4 alleles.
Through blood work I've found out that I carry two E4 alleles
Am I pretty much screwed, how much will eating a healthy diet and training do to decrease my chances of all the horrible illness associate with people who only carry one E4 allele.
via World Class Bodybuilding Forum http://www.worldclassbodybuilding.com/forums/f441/apolipoprotein-e-137156/
0 commentaires:
Enregistrer un commentaire