The July, 2013 issue of The FASEB Journal published the discovery of researchers at Boston's Brigham & Women's Hospital and Harvard Medical School of a mechanism for docosahexaenoic acid (DHA, an omega-3 fatty acid that occurs in fish oil and algae) in reducing inflammation. Omega-3 fatty acids have been known to have an anti-inflammatory effect, yet how this occurs has not been well defined.
Charles N. Serhan, PhD and his colleagues found that human immune cells known as macrophages convert DHA to an intermediate compound labeled 13S, 14S-epoxy-maresin. "Maresins are produced by macrophages from docosahexaenoic acid (DHA) and exert potent proresolving and tissue homeostatic actions," Dr Serhan and his coauthors write. "Maresin 1 is the first identified maresin."
As the result of synthesizing the intermediate molecule, they found that it promoted the conversion of macrophages from the M1 phenotype to the M2 phenotype that does not stimulate inflammation. "We hope that the results from this study will enable investigators to test the relevance of the maresin pathway in human disease," Dr Serhan stated. "Moreover, we hope to better understand resolution biology and its potential pharmacology so that we can enhance our ability to control unwanted inflammation and improve the quality of life."
"We've known for a long time that DHA tames inflammation, now, we learn exactly how DHA works: via new substances called maresins," commented Gerald Weissmann, MD, who is The FASEB Journal'sEditor-in-Chief of. "We encounter inflammation almost daily, but our body has ways of turning it off. This is an important step toward understanding exactly this happens. You're likely to be hearing a lot more about maresins if, or when, new therapies arise from this discovery."
[feg.org]
Charles N. Serhan, PhD and his colleagues found that human immune cells known as macrophages convert DHA to an intermediate compound labeled 13S, 14S-epoxy-maresin. "Maresins are produced by macrophages from docosahexaenoic acid (DHA) and exert potent proresolving and tissue homeostatic actions," Dr Serhan and his coauthors write. "Maresin 1 is the first identified maresin."
As the result of synthesizing the intermediate molecule, they found that it promoted the conversion of macrophages from the M1 phenotype to the M2 phenotype that does not stimulate inflammation. "We hope that the results from this study will enable investigators to test the relevance of the maresin pathway in human disease," Dr Serhan stated. "Moreover, we hope to better understand resolution biology and its potential pharmacology so that we can enhance our ability to control unwanted inflammation and improve the quality of life."
"We've known for a long time that DHA tames inflammation, now, we learn exactly how DHA works: via new substances called maresins," commented Gerald Weissmann, MD, who is The FASEB Journal'sEditor-in-Chief of. "We encounter inflammation almost daily, but our body has ways of turning it off. This is an important step toward understanding exactly this happens. You're likely to be hearing a lot more about maresins if, or when, new therapies arise from this discovery."
[feg.org]
via World Class Bodybuilding Forum http://www.worldclassbodybuilding.com/forums/f483/how-dha-controls-inflammation-133810/
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