Additive insulinogenic action of Opuntia ficus-indica cladode and fruit skin extract

Background:Oral intake of a specific extract of Opuntia ficus-indica cladode and fruit skin (OpunDiaTM) (OFI) has been shown to increase serum insulin concentration while reducing blood glucose level for a given amount of glucose ingestion after an endurance exercise bout in healthy young volunteers. However, it is unknown whether OFI-induced insulin stimulation after exercise is of the same magnitude than the stimulation by other insulinogenic agents like leucine as well as whether OFI can interact with those agents. Therefore, the aims of the present study were: 1) to compare the degree of insulin stimulation by OFI with the effect of leucine administration; 2) to determine whether OFI and leucine have an additive action on insulin stimulation post-exercise.Methods:Eleven subjects participated in a randomized double-blind cross-over study involving four experimental sessions. In each session the subjects successively underwent a 2-h oral glucose tolerance test (OGTT) after a 30-min cycling bout at ~70% VO2max. At t0 and t60 during the OGTT, subjects ingested 75g glucose and capsules containing either 1) a placebo; 2) 1000mg OFI; 3) 3g leucine; 4) 1000mg OFI + 3g leucine. Blood samples were collected before and at 30-min intervals during the OGTT for determination of blood glucose and serum insulin.Results:Whereas no effect of leucine was measured, OFI reduced blood glucose at t90 by ~7% and the area under the glucose curve by ~15% and increased serum insulin concentration at t90 by ~35% compared to placebo (P

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