Science Made Simple: What next for PDEi failures?
BJU Int. 2014 Jan 21;
Authors: Wyllie MG
Abstract
The mechanism of action of sildenafil is well documented (Figure 1). An action as a selective inhibitor of the phosphodiesterase (PDE) V iso-enzyme results in potentiation of non-adrenergic non-cholinergic (NANC) neurotransmission. This in turn, under certain situations, produces a pro-erectile response. In cavernosal tissue there is a counter-balancing (flaccidity-inducing) action of the neurotransmitter, noradrenaline, and other locally acting hormones, particularly testosterone can either augment or diminish the NANC activity.
PMID: 24447581 [PubMed - as supplied by publisher]
This is an automated post
BJU Int. 2014 Jan 21;
Authors: Wyllie MG
Abstract
The mechanism of action of sildenafil is well documented (Figure 1). An action as a selective inhibitor of the phosphodiesterase (PDE) V iso-enzyme results in potentiation of non-adrenergic non-cholinergic (NANC) neurotransmission. This in turn, under certain situations, produces a pro-erectile response. In cavernosal tissue there is a counter-balancing (flaccidity-inducing) action of the neurotransmitter, noradrenaline, and other locally acting hormones, particularly testosterone can either augment or diminish the NANC activity.
PMID: 24447581 [PubMed - as supplied by publisher]
This is an automated post
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