IGF - Insulin like growth factor 2 regulation of Aryl Hydrocarbon Receptor in MCF-7 b

Related Articles Insulin like growth factor 2 regulation of Aryl Hydrocarbon Receptor in MCF-7 breast cancer cells.



Biochem Biophys Res Commun. 2013 Dec 28;



Authors: Tomblin JK, Salisbury TB





Abstract

Insulin like growth factor (IGF)-1 and IGF-2 stimulate normal growth, development and breast cancer cell proliferation. Cyclin D1 (CCND1) promotes cell cycle by inhibiting retinoblastoma protein (RB1). The aryl hydrocarbon receptor (AHR) is a major xenobiotic receptor that also regulates cell cycle. The purpose of this study was to investigate whether IGF-2 promotes MCF-7 breast cancer proliferation by inducing AHR. Western blot and quantitative real time PCR (Q-PCR) analysis revealed that IGF-2 induced an approximately 2-fold increase (P